Diocletian, Roman Emperor, publishes his edict that begins the persecution of Christians in his portion of the Empire.

Martin Luther's first appearance before the Diet of Worms to be examined by the Holy Roman Emperor Charles V and the other estates of the empire.

Estevão da Gama departs Massawa, leaving behind 400 matchlock men and 150 slaves under his brother Christovão da Gama, with orders to help the Emperor of Ethiopia defeat Ahmad ibn Ibrihim al-Ghazi who had invaded his Empire.

The All India Muslim League is founded in Dacca, East Bengal, British India Empire, which later laid down the foundations of Pakistan.