Because of a lineup revision by Miller Huggins, Wally Pipp is replaced by Lou Gehrig at first base for the New York Yankees, beginning a streak of 2,130 consecutive games played, topped only by Cal Ripken, Jr. in by 1995. Exactly 16 years later to the day, in 1941, Gehrig dies from Amyotropic lateral sclerosis (ALS).

Lou Gehrig and teammate Tony Lazzeri hit four home runs in one game, and hit for the natural cycle, respectively. These two feats are both less common than a perfect game, which has occurred twenty one times in one hundred and twenty years.

Lou Gehrig hits his 23rd career grand slam – a record that still stands.

Lou Gehrig, recently diagnosed with Amyotrophic lateral sclerosis, tells a crowd at Yankee Stadium that he considers himself "The luckiest man on the face of the earth" as he announces his retirement from major league baseball.