Babe Ruth of the Boston Red Sox is sold to the New York Yankees by owner Harry Frazee.

Ray Chapman of the Cleveland Indians is hit on the head by a fastball thrown by Carl Mays of the New York Yankees, and dies early the next day. To date, Chapman is the second player to die from injuries sustained in a Major League Baseball game, the first being Doc Powers in 1909.

Because of a lineup revision by Miller Huggins, Wally Pipp is replaced by Lou Gehrig at first base for the New York Yankees, beginning a streak of 2,130 consecutive games played, topped only by Cal Ripken, Jr. in by 1995. Exactly 16 years later to the day, in 1941, Gehrig dies from Amyotropic lateral sclerosis (ALS).

The World Series, featuring the New York Yankees and the Brooklyn Dodgers, is televised for the first time.

New York Yankees's Don Larsen pitched the only perfect game in a World Series; one of only 20 perfect games in MLB history.

George Brett batting for the Kansas City Royals against the New York Yankees, has a game-winning home run nullified in the "Pine Tar Incident".