St. Patrick returns to Ireland as a missionary bishop.

The Parliament of Ireland meets at Castledermot in County Kildare, the first definitively known meeting of this Irish legislature.

The ten-year-old Lambert Simnel is crowned in Christ Church Cathedral in Dublin, Ireland with the name of Edward VI in a bid to threaten King Henry VII's reign.

After a three-day siege, the English Army beheads over 600 Irish and Papal soldiers and civilians at Dún an Óir, Ireland.

Charles I becomes King of England, Scotland and Ireland as well as claiming the title King of France.

The sack of Baltimore: the Irish village of Baltimore is attacked by Algerian pirates.

New Ross town, Co. Wexford, Ireland, surrenders to Oliver Cromwell.

King Charles II of England, Scotland and Ireland is crowned in Westminster Abbey.

Battle of Aughrim (Julian calendar) – The decisive victory of William III of England's forces in Ireland.

George Frideric Handel's oratorio ''Messiah'' makes its world-premiere in Dublin, Ireland.

The Battle of Oulart Hill takes place in Wexford, Ireland.

French troops land in Kilcummin harbour, County Mayo, Ireland to aid Wolfe Tone's United Irishmen's Irish Rebellion.

Opening of the Dublin and Kingstown Railway, the first public railway on the island of Ireland.

In the Fenian Invasion of Canada, John O'Neill leads 850 Fenian raiders across the Niagara River at Buffalo, New York/Fort Erie, Ontario, as part of an effort to free Ireland from the United Kingdom. Canadian militia and British regulars repulse the invaders in over the next three days, at a cost of 9 dead and 38 wounded to the Fenian's 19 dead and about 17 wounded.

Dracula, a novel by Irish author Bram Stoker is published.

Irish leader John Edward Redmond calls for a revolt against British rule.

Irish nationalist Arthur Griffith founds Sinn Féin as a political party with the main aim of establishing a dual monarchy in Ireland.

Guglielmo Marconi's company begins the first commercial transatlantic wireless service between Glace Bay, Nova Scotia, Canada and Clifden, Ireland.

The United Kingdom's House of Commons passes the Home Rule Act for devolution in Ireland.

World War I: The British super-dreadnought battleship HMS Audacious (23,400 tons), is sunk off Tory Island, north-west of Ireland, by a minefield laid by the armed German merchant-cruiser ''Berlin''.

The RMS Lusitania departs from New York City on her two hundred and second, and final, crossing of the North Atlantic. Six days later, the ship is torpedoed off the coast of Ireland with the loss of 1,198 lives, including 128 Americans, rousing American sentiment against Germany.

Easter Rising: The Irish Republican Brotherhood led by nationalists Patrick Pearse, James Connolly, and Joseph Plunkett starts a rebellion in Ireland.

Easter Rebellion: The United Kingdom declare martial law in Ireland.

Easter Rebellion: Martial law in Ireland is lifted and the rebellion is officially over with the surrender of Irish nationalists to British authorities in Dublin.

The RMS Carpathia, the ship that rescued the 705 survivors from the RMS Titanic, is sunk off Ireland by the German SMU U-55; 5 lives are lost.

Meeting of the First Dáil Éireann in the Mansion House Dublin. Sinn Féin adopts Ireland's first constitution. The first engagement of Irish War of Independence, Sologhead Beg, County Tipperary.

John Alcock and Arthur Brown complete the first nonstop transatlantic flight when they reach Clifden, County Galway, Ireland.

At Windsor Castle, King George V receives the colours of the six Irish regiments that are to be disbanded – the Royal Irish Regiment, the Connaught Rangers, the South Irish Horse, the Prince of Wales's Leinster Regiment, the Royal Munster Fusiliers and the Royal Dublin Fusiliers.

Amelia Earhart takes off from Newfoundland to begin the world's first solo nonstop flight across the Atlantic Ocean by a female pilot, landing in Ireland the next day.

A Luftwaffe air raid in Dublin, Ireland claims 38 lives.

A fire breaks out at St. Joseph's Orphanage, Co Cavan, Ireland, killing 36 people (35 of whom are children).

Eamon de Valera resigns as Taoiseach of Ireland.

The remaining human inhabitants of the Blasket Islands, Kerry, Ireland are evacuated to the mainland.

Albania, Austria, Bulgaria, Cambodia, Finland, Hungary, Ireland, Italy, Jordan, Laos, Libya, Nepal, Portugal, Romania, Spain and Sri Lanka join the United Nations.

A bomb planted by young Irish protesters destroys Nelson's Pillar in Dublin.

Thirty-three people are killed by terrorist bombings in Dublin and Monaghan, Ireland.

The tanker ''Betelgeuse'' explodes in Bantry Bay, Ireland.

In Dublin, Ireland, Provisional Irish Republican Army member Thomas McMahon is sentenced to life in prison for the assassination of Lord Mountbatten.

A terrorist bomb aboard Air India flight 182 brings the Boeing 747 down off the coast of Ireland killing all 329 aboard.

The Michael Hughes Bridge in Sligo, Ireland is officially opened.